Chloramphenicol combined with ampicillin in treatment of typhoid.

Treatment of typhoid fever: a comparative trial of ampicillin and chloramphenicol.

Therapeutic implications of ofloxacin in the treatment of typhoid fever caused by multiply resistant Salmonella typhi.

The antibiotic of choice for the treatment of typhoid fever in most parts of the world is still chloramphenicol. Ampicillin and cotrimoxazole have been used in recent years. Selection of antimicrobials for therapy has been complicated by the emergence of Salmonella typhi strains resistant to the above mentioned antibiotics. Blood and/or bone marrow cultures of 30 adult patients grew S. typhi th...

Re-emergence of susceptibility to conventionally used drugs among strains of Salmonella Typhi in central west India.

INTRODUCTION Typhoid fever (enteric fever) is a global health problem causing high morbidity and mortality, especially in endemic areas such as India. The problem is exacerbated as the causative agent, Salmonella enterica subspecies enterica serovar Typhi (S. Typhi), rapidly develops resistance to drugs used in treatment. However, non-responsiveness of S. Typhi to quinolones has been reported s...

Comparison of Ampicillin and Chloramphenicol in Treatment of Paratyphoid Fever.

ALPHA-AMINOBENZYL penicillin or ampicillin* belongs to the group of synthetic derivatives of 6-aminopenicillanic acid. They are distinguished by a prevalently bactericidal activity, not only on gram positive bacteria, sensitive to penicillin, but also on gram negative bacteria, including salmonellae. Ampicillin is remarkably more active than chloramphenicol or tetracycline in mice infected with...

Oxolinic acid in the treatment of typhoid fever due to chloramphenicol-resistant strains of Salmonella typhi.

Of 28 strains of Salmonella typhosa collected in late 1972 in Vietnam, 4 had minimum inhibitory concentrations to chloramphenicol of >100 mug/ml. Median minimum inhibitory concentrations of all strains to oxolinic acid were 0.39 mug/ml; ampicillin, 6.25 mug/ml; amoxicillin, 0.39 mug/ml. Widespread typhoid fever appeared in mid-1973 with more than three-fourths of strains found to be resistant t...